Minerva anestesiologica
-
Minerva anestesiologica · Dec 2015
Randomized Controlled Trial Multicenter Study Comparative StudyThe effects of plasmalyte-148 versus hartmann's solution during major liver resection: a multicentre, double-blind, randomized controlled trial.
The acid-base, biochemical and hematological effects of crystalloid solutions have not been comprehensively evaluated in patients with liver resection. ⋯ In liver resection patients, HS and PL led to similar base excess values but different post operative plasma biochemistry and hematology values. Understanding of these effects may help clinicians individualize fluid therapy in these patients.
-
Minerva anestesiologica · Dec 2015
Randomized Controlled TrialMelatonin reduces the need for sedation in ICU patients. A randomized controlled trial.
Critically ill patients suffer from physiological sleep deprivation and have reduced blood melatonin levels. This study was designed to determine whether nocturnal melatonin supplementation would reduce the need for sedation in patients with critical illness. ⋯ Long-term enteral melatonin supplementation may result in a decreased need for sedation, with improved neurological indicators and cost reduction. Further multicenter evaluations are required to confirm these results with different sedation protocols.