Minerva anestesiologica
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Minerva anestesiologica · Sep 2024
ReviewHas the role of troponin as a biomarker of cardiac complications after non-cardiac surgery been fully understood?
Myocardial injury after non-cardiac surgery is a major issue with a rate of almost 20%, as suggested by the literature. Guidelines recommend screening patients undergoing non-cardiac surgery who have at least one cardiovascular risk factor. Clinical trials are characterized by a high degree of heterogeneity. ⋯ Troponin elevation can be a result of patient-related factors and comorbidities, including age, chronic renal failure, and inflammatory status. Currently, there is no effective strategy to prevent perioperative myocardial injury, and there are no therapeutic options that significantly improve the outcome of patients with myocardial injury. We have focused on this topic and on perioperative myocardial injury to highlight the areas of research that remain unexplored.
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Minerva anestesiologica · Sep 2024
Meta AnalysisAssociation between elevated preoperative VE/VCO2 slope and increased mortality following major surgery: a meta-analysis.
The relationship between preoperative VE/VCO
2 slope and mortality in adults undergoing major surgery is not well-established. ⋯ Elevated preoperative VE/V CO2 slope is associated with an increased risk of postoperative short- and long-term mortality in adults undergoing major surgery. -
Minerva anestesiologica · Sep 2024
Editorial Comment LetterAltered brain perfusion in sepsis: walking on the moon.
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Minerva anestesiologica · Sep 2024
Editorial Comment LetterThe VE/VCO2 slope: the preoperative risk assessment's Holy Grail?
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Minerva anestesiologica · Sep 2024
ReviewThe clinical value of nonpharmacological interventions for preventing postoperative delirium: a narrative review.
Postoperative delirium (POD) is a prevalent perioperative complication among elderly individuals and is a cause of significant detrimental consequences for both individuals and society. Pharmacological and nonpharmacological prevention methods/therapies have been proposed to mitigate the risk of POD. Nevertheless, the efficacy of pharmacological interventions is controversial, and some of them cause side effects. ⋯ The former is aimed at increasing cognitive reserve, thus decreasing the incidence rate of POD. Noncognitive interventions, including sensory stimuli (music therapy, odor enrichment), improving sleep disturbances, physical activity, acupuncture and transcranial magnetic/direct current stimulation, are aimed at decreasing the risk factors for POD. This review provides a comprehensive overview of recently reported nonpharmacological mono-component interventions for preventing POD and briefly describes their clinical value.