Oral Surg Oral Med O
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Oral Surg Oral Med O · Jul 1997
Randomized Controlled Trial Multicenter Study Clinical TrialMultidrug intravenous sedation: determinants of the sedative dose of midazolam.
The efficacy of multidrug intravenous sedation regimens in oral surgery is based on the ability to titrate opioids, benzodiazepines, and barbiturates to a desired level of relaxation. Dosage requirements to reach the initial sedation end points of slurred speech and ptosis of eyelids vary widely from one patient to another. ⋯ Dosage requirements for the initial titration of midazolam were found to be significantly higher when fentanyl was not included in the sedation regimen and when presedation heart rate and presedation systolic blood pressure were elevated.