Oral Surg Oral Med O
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Oral Surg Oral Med O · Dec 2002
Thymidylate synthase and dihydropyrimidine dehydrogenase expression in oral squamous cell carcinoma: an immunohistochemical and clinicopathologic study.
Thymidylate synthase (TS) is the target enzyme for 5-fluorouracil (5-FU), and dihydropyrimidine dehydrogenase (DPD) is the first enzyme that metabolizes 5-fluorouracil. Until now, only the enzyme activities of TS and DPD have been investigated; however, there are few reports about the immunohistochemistry of TS and DPD and none regarding oral carcinoma. The purpose of this article was to investigate the expression of TS and DPD in oral squamous cell carcinoma. ⋯ TS may reveal tumor cell proliferation, but DPD-LI may correlate with a response to anticancer drug treatment.
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Oral Surg Oral Med O · Dec 2002
Comparative StudyTissue-dissolving capacity and antibacterial effect of buffered and unbuffered hypochlorite solutions.
The goal of this study was to compare the dissolving potential of Dakin's solution with that of equivalent buffered and unbuffered sodium hypochlorite solutions on fresh and decayed tissues. In addition, the antimicrobial effect of Dakin's solution and equivalent unbuffered hypochlorite was tested. ⋯ In contrast to earlier statements, the results of this study do not demonstrate any benefit from buffering sodium hypochlorite with sodium bicarbonate according to Dakin's method. An irrigation solution with less dissolving potential may be obtained by simply diluting stock solutions of NaOCl with water.