World Neurosurg
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Randomized Controlled Trial
Effect of scalp blocks with levobupivacaine on recovery profiles after craniotomy for aneurysm clipping: a randomized, double-blind, and controlled study.
This study was conducted to evaluate the effect of scalp blocks using levobupivacaine on recovery profiles including postoperative pain, patient-controlled analgesia (PCA) consumption, postoperative nausea and vomiting (PONV), and other adverse events in patients undergoing frontoparietal craniotomy for aneurysm clipping. ⋯ Scalp blocks with 0.75% levobupivacaine improved recovery profiles in that it effectively lowered postoperative pain and PCA consumption without severe adverse events and also reduced the requirement for a postoperative antihypertensive agent and the incidence of PONV in patients who underwent frontoparietal craniotomy for aneurysm clipping.
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This study sought to assess the results of current laboratory studies of olfactory ensheathing cell (OEC) transplantation for the treatment of central nervous system repair. ⋯ Although the exact mechanisms of action of OECs are not fully understood, it is clear that OECs have beneficial regenerative properties in laboratory studies, and the ease with which OECs can be harvested and cultured in animal models make clinical application a very reasonable prospect.