World Neurosurg
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Angiosarcoma often arises as a cutaneous disease in the scalp and the face; however, subdural hematoma (SDH) associated with angiosarcoma is extremely rare. ⋯ In addition to cancers metastatic to the skull or dura mater, angiosarcoma should be included in the differential diagnosis for patients with repeated SDH and bone defect. An effective treatment for angiosarcoma with SDH that shows an unfavorable prognosis has not been established; however, an early diagnosis might be useful for a novel treatment.
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The objective of this study was to evaluate the association between asymptomatic unruptured intracranial aneurysms (IAs) and pituitary adenomas (PAs) in Chinese people. ⋯ The patients with PA have an increased incidence of IA compared with age-matched control subjects. Older age and cavernous sinus invasion might be correlated with the increased prevalence of IAs in Chinese patients with PA.
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Brain arteriovenous malformations (BAVMs) are vascular malformations composed of tangles of abnormally developed vasculature without capillaries. Abnormal shunting of arteries and veins is formed, resulting in high-pressure vascular channels, which potentially lead to rupture. BAVMs are generally considered a congenital disorder. But clinical evidence regarding involution, regrowth, and de novo formation argue against the static condition of this disease. Recently, the presence of the somatic activating KRAS mutations in more than half of BAVM cases was reported, suggesting the role of KRAS function in the pathogenesis. ⋯ KRAS mutations in codon35 were detected in about two thirds of specimens examined. KRAS function may actively contribute to the pathobiology of BAVM and can become a therapeutic target.
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The aim of present study was to assess the predictive value of the admission prognostic nutrition index (PNI), controlling nutritional status (CONUT) associated with delayed cerebral ischemia (DCI), and 3-month neurological outcomes after aneurysmal subarachnoid hemorrhage (aSAH). ⋯ Our results have indicated that the CONUT score might efficiently predict for the clinical outcomes at 3 month after aSAH.
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Consideration of sagittal alignment is an integral part of spinal fusion surgery correlating with superior outcomes. Segmental lordosis is an important contributor to sagittal alignment. This study assessed surgical factors influencing segmental lordosis in a 360° fusion model, including cage dimensions, anterior longitudinal ligament resection, facetectomy, and posterior compression. ⋯ Cage height was a key factor, with posterior compression further increasing lordosis. The finding that 0° cages results in the most segmental lordosis was an unexpected finding and highlights the importance of appropriate sizing on resulting lordosis. These findings are relevant to cage selection but require further study prior to applying to clinical practice and may influence future cage design.