World Neurosurg
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We investigated the effects of different doses of pregabalin on the pathophysiologic changes in early brain injury after subarachnoid hemorrhage (SAH) in rats. ⋯ Although the antioxidant effect was significant with the lower dose of pregabalin, the anti-inflammatory effects via vasodilatation were more marked with the higher dose. Significant improvements in the histopathological changes were observed with the higher dose of pregabalin. The dose-dependent effects of pregabalin on SAH should be evaluated in animal studies as a function of time and in the acute and chronic phases.
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Few studies have evaluated the cost burden borne by neurosurgical patients in the developing world and their potential implications for efficient and effective delivery of care. This study aims to assess the cost associated with obtaining pediatric neurosurgical care in a hospital in Kaduna. ⋯ The mean cost of pediatric neurosurgical procedures in our setting is $895.99, which is 40.18% of our gross domestic product per capita. The main drivers of cost are the cost of operation, investigations, and intensive care unit length of stay.
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Most microsurgical instrument designs concentrate on manipulating the targeted tissue more than the detailed design of the user's hand. Microergonomics is a new area of study on hand design in order to redesign the instruments in a better way for the surgeon's hand. ⋯ The future perspectives of designing neurosurgical instruments will be directed toward microergonomics, penization, and electronics integrated with surgical instrument principles.