World Neurosurg
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Posterior inferior cerebellar artery (PICA) aneurysms are usually complex to treat because of their deep location, frequent entanglement with the lower cranial nerves, the presence of perforating arteries to the brainstem, and their often dissecting or fusiform morphology.1 These aneurysms can require revascularization of the PICA.2 The length and size of the occipital artery (OA) make it an excellent donor.3,4 Video 1 shows the technical nuances of an OA-PICA bypass for the treatment of a ruptured fusiform aneurysm of the left PICA. The patient is a 34-year-old male presenting with an abrupt headache and confusion (Hunt and Hess grade III and World Federation Neurology Surgeons grade II). Computed tomography of the brain revealed hydrocephalus and subarachnoid hemorrhage (Fisher IV) and digital subtraction angiography revealed a fusiform aneurysm on the tonsillomedullary segment of the left PICA. ⋯ The patient remained neurologically intact, and imaging showed good flow through the bypass and no evidence of stroke. OA-PICA bypass is a useful strategy to treat ruptured fusiform PICA aneurysms since it avoids sacrificing the PICA and the use of dual-antiplatelet therapy. This video is one of the few videos published on OA-PICA bypass.6,7 It explains the technical aspects, open and endovascular alternatives, and rationale for this procedure.
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Observational Study
Observational Studies in Neurosurgery: Structure, Functioning, and Uses.
Although randomized interventional studies are the gold standard of clinical study designs, they are not always feasible or necessary. In such cases, observational studies can bring insights into critical questions while minimizing harm and cost. There are numerous observational study designs, each with strengths and demerits. Unfortunately, it is not uncommon for observational study designs to be poorly designed or reported. In this article, the authors discuss similarities and differences between observational study designs, their application, and tenets of good use and proper reporting focusing on neurosurgery. ⋯ This paper disambiguates widely held misconceptions on the different observational study designs. In addition, it uses case-based scenarios to facilitate comprehension and relevance to the academic neurosurgery audience.
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Magnetic resonance-guided laser interstitial thermal therapy (MRgLITT) is a minimally invasive and effective treatment option that can potentially treat deep-seated pathologies in cases without safe open surgical corridors. In the present report, we have described our experience using MRgLITT for brainstem pathologies. ⋯ The brainstem represents formidable territory even for minimally invasive procedures. The overall morbidity and mortality has remained high, and the probability of achieving a meaningful outcome must be carefully assessed.
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Survival analyses are heavily used to analyze data in which the time to event is of interest. The purpose of this paper is to introduce some fundamental concepts for survival analyses in medical studies. ⋯ This work is an attempt to encourage more investigators/medical practitioners to use survival analyses appropriately in medical research. We highlight some statistical issues, make recommendations, and provide more advanced survival modeling in this aspect.
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The application and interpretation of P values have caused debate for several decades, and this debate has become particularly relevant in the past few years. The P value represents the probability of seeing results as extreme or more extreme than those observed in a data analysis, were the null hypothesis and other underlying assumptions to be true. While P values are useful in pointing out where an effect may be present, they have often been misused in an attempt to oversell "statistically significant" findings. ⋯ Only a minority of manuscripts that reported statistical significance described confounder adjustment, or effect sizes. A common, incorrect assumption often observed was that statistical significance equals clinical relevance. To enable correct interpretation of clinical significance, it is crucial that authors describe the clinical implications of their findings.