World Neurosurg
-
The intercavernous sinuses (ICSs) connect the cavernous sinuses on both sides. Although the management of ICSs is an important aspect in extended transsphenoidal surgery (eTSS), there has been no report to evaluate ICSs in sellar lesions. In this study, we analyzed ICSs using computed tomographic digital subtraction venography (CT-DSV) in sellar lesions. ⋯ CT-DSV can be useful for evaluating ICSs in sellar lesions. Preoperative evaluation of ICSs may provide important information for eTSS.
-
Neuroprotective Effects of Thymoquinone on The Hippocampus in A Rat Model of Traumatic Brain Injury.
Traumatic brain injury is a leading cause of morbidity and mortality worldwide. We evaluated the neuroprotective effects of thymoquinone (TQ) in a rat model of traumatic brain injury by using biochemical and histopathologic methods for the first time. ⋯ These results indicate that TQ has a healing effect on neural cells after head injury and this effect is mediated by decreasing MDA levels in the nuclei and mitochondrial membrane of neurons.
-
High-mobility group box 1 (HMGB1) was shown to be a major extracellular mediator involved in relayed neuro-inflammation in animals after subarachnoid hemorrhage (SAH). It is of interest to examine the effect of rhinacanthin-C (RCT-C, C25H30O5) on pro-inflammatory cytokines/HMGB1 in an SAH-related early brain injury model. ⋯ RCT-C exerts a neuroprotective effect by reducing cleaved caspase-3- and caspase-9a-related apoptosis. Decreased HMGB-1 mRNA and protein expression in the RCT-C groups corresponds to its anti-inflammatory effect. HMGB-1 recombinant protein administration impaired the neuroprotective and immunosuppressive effect of RCT-C. This finding lends credence that RCT-C modulates the HMGB-1-related pathway and attenuates brain apoptosis in the pathogenesis of SAH.