World Neurosurg
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Randomized Controlled Trial
Adjuvant immunotherapy with whole-cell lysate dendritic cells vaccine for glioblastoma multiforme: a phase II clinical trial.
This study sought to evaluate effectiveness of autologous dendritic cell vaccine (immunotherapy) for glioblastoma multiforme (GBM). ⋯ Adjuvant immunotherapy with whole-cell lysate dendritic cell vaccine may improve short-term survival. It seems to be safe, and its long-term effectiveness is worthy of further investigation.
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To present the authors' experience in surgical treatment of patients with trigeminal neuralgia (TN) with intraneural vessels. ⋯ If the intraneural vessel is an artery, it can be decompressed by wrapping techniques. Otherwise, intraneural veins should be coagulated and divided. Most patients can achieve excellent or good pain relief with this approach; facial numbness is uncommon.
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Microsurgical fenestration of the third ventricular floor performed in one session with resection of deep seated tumors has been recently demonstrated as an approach to specifically address the concomitant obstructive hydrocephalus. As with endoscopic third ventriculostomy, occlusion of the stoma may result in progression of the obstructive hydrocephalus. In order to provide reliable communication between the basal cisterns and ventricles, we propose stenting of the stoma in cases of direct surgical approach to deep seated tumors. ⋯ Microsurgical fenestration of the third ventricle floor combined with stoma stenting can be a viable option for hydrocephalus control.