World Neurosurg
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In the present study, we evaluate the characteristics of cognitive and affective function in patients with somatotroph adenomas (SAs) that secrete excess growth hormone and the effects of surgical intervention. ⋯ Patients with SAs showed specific cognitive deficits and abnormal moods, which might be attributed to the overproduction of growth hormone. However, surgical intervention had a limited effect on improving the impaired cognitive function and abnormal moods in patients with SAs at short-term follow-up.
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Application of surgical skull pins causes hemodynamic fluctuations in neurosurgical procedures. To reduce this response, we describe the use of a novel nonpharmacologic method in the form of medical-grade sterile silicone studs to cushion the pressure of the skull pin in the adult population. This study aimed to evaluate the use of conventionally used fentanyl and medical-grade sterile silicone studs for the prevention of hemodynamic response to skull pin insertion. ⋯ The use of medical-grade silicone studs causes fewer hemodynamic fluctuations compared with fentanyl on skull pinning. Further studies with larger sample sizes are required to confirm the findings of this pilot study.
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This study aimed to evaluate the utility of computed tomography (CT)-based Hounsfield units (HUs) and magnetic resonance imaging-based Vertebral Bone Quality (VBQ) scores as alternatives to dual-energy x-ray absorptiometry for predicting the risk of proximal junctional failure (PJF) in female patients with adult spinal deformity (ASD) undergoing 2-stage corrective surgery with lateral lumbar interbody fusion (LLIF). ⋯ The findings suggest that measuring HU values at UIV or L4 by CT may be useful for predicting the risk of PJF in female ASD patients undergoing 2-stage corrective surgery with LLIF. Therefore, CT-based HUs should be considered in ASD surgery planning to reduce the risk of PJF.
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The purpose of our study was to analyze the impact of time interval from referral to surgery and from surgery to adjuvant treatment on survival of adult isocitrate dehydrogenase-wild-type (IDH-wt) glioblastomas. ⋯ Interval from referral to surgery in the range of 4-10 weeks was not associated with decreased survivals in IDH-wt glioblastomas. In contrast, delay exceeding 30 days from surgery to adjuvant treatment may decrease long-term survival.
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Thoracolumbar vertebral fractures are one of the most common fractures; however, there is a lack of mechanical analyses for what the posterior fixation is for different spine alignments. ⋯ It may be more beneficial to use 6PS compared with 4PS to reduce stresses on the fractured vertebrae and instrumentation, regardless of the spinal alignment.