World Neurosurg
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To scrutinize and compare the accuracy of measurements obtained from photogrammetric models against direct measurements taken on dry skulls, with the aim to verify the feasibility of photogrammetry for quantitative analysis in microsurgical neuroanatomy. ⋯ The role of two photogrammetric models is validated as quantitative analysis technique for laboratory neuroanatomical studies showing acceptable measurement error, high intra- and inter-rater reliability as well as good to very good agreement compared to direct measurement on dry skulls, replacing the expensive and time-consuming methods like CT scans and neuronavigation system.
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This study explores the integration of chimeric antigen receptor T-cell (CAR-T) therapy with convection enhanced delivery (CED) as a novel approach for treating diffuse intrinsic pontine glioma (DIPG), a highly aggressive pediatric brain tumor with limited treatment options. Preliminary clinical results indicate that CED improves CAR-T cell distribution within the tumor microenvironment, leading to promising anti-tumor responses. ⋯ Ongoing research is essential to optimize these strategies and address ethical considerations surrounding patient safety and equitable access to innovative therapies. The aim is to assess the safety, efficacy, and distribution of CAR-T cells delivered directly to the tumor site via CED, thereby enhancing therapeutic outcomes while minimizing systemic side effects.
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Opiate drugs are commonly prescribed for postoperative pain relief following craniotomy. The aim of this study was to assess opiate use in patients undergoing craniotomy for high-grade glioma and to identify risk factors contributing to prolonged opiate use. ⋯ Postoperative opiate use in this cohort is modest. Increased opiate use is associated with comorbidities known to modulate pain perception. Prospective studies should be conducted to provide more robust data.
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This study aims to develop a fully automated, CT-based deep learning（DL） model to segment ossified lesions of the posterior longitudinal ligament (OPLL) and to measure the thickness of the ossified material and calculate the cervical spinal cord compression factor. ⋯ The proposed DL model effectively detects and separates ossification foci in OPLL on CT images. It exhibits comparable performance to radiologists in quantifying spinal cord compression metrics.
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Currently, there is no established treatment consensus for craniocervical unruptured dissecting aneurysms (UDAs). This study aimed to assess the safety and efficacy of the Surpass Streamline Flow Diverter (SSFD) for treating craniocervical UDAs. ⋯ Our findings suggest that SSFD is a safe and effective tool for craniocervical UDAs, demonstrating a high occlusion rate, acceptable complication rate, and good clinical outcome.