Ann Pathol
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Comparative Study
[Lymphomatoid granulomatosis, polymorphic reticulosis and angioimmunoblastic lymphadenopathy with pulmonary involvement. Similar or different entities?].
This study attempts to demonstrate that typical lymphomatoid granulomatosis, polymorphic reticulosis and angioimmunoblastic lymphadenopathy with pulmonary involvement, are three related anatomo-clinical conditions. Three groups of patients with clinical and pathological signs corresponding to each of these three conditions are studied. In group A, the clinical, radiographic and histologic data for 11 patients presenting "classical lymphomatoid granulomatosis" are reported. ⋯ Lymph node lesions were typical for AIL: destruction of follicular structure, vascular proliferation and numerous immunoblasts. Lesions in other organs (mainly lung, dermal and ENM lesions) were characterized by angiocentric granulomas containing numerous blast cells. The biological behavior with eventual development of a monoclonal gammopathy, associated or not with a malignant immunoblastic lymphoma, as well as resemblance of clinical and histological manifestations during the course of the disease, suggest that these three conditions represent variants of a basically identical entity.