The Journal of clinical endocrinology and metabolism
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J. Clin. Endocrinol. Metab. · May 2021
Dysnatremia is a Predictor for Morbidity and Mortality in Hospitalized Patients with COVID-19.
Dysnatremia is an independent predictor of mortality in patients with bacterial pneumonia. There is paucity of data about the incidence and prognostic impact of abnormal sodium concentration in patients with coronavirus disease 2019 (COVID-19). ⋯ Abnormal sodium levels during hospitalization are risk factors for poor prognosis, with hypernatremia and hyponatremia being associated with a greater risk of death and respiratory failure, respectively. Serum sodium values could be used for risk stratification in patients with COVID-19.
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J. Clin. Endocrinol. Metab. · Apr 2021
Comparative StudyGlucose Metabolism After Pancreatectomy: Opposite Extremes Between Pancreaticoduodenectomy and Distal Pancreatectomy.
The rate of glucose metabolism changes drastically after partial pancreatectomy. ⋯ Blood glucose levels after the OGTT differed markedly between PD and DP populations. The observed differences between PD and DP suggest the importance of individualization in the management of metabolism and nutrition after partial pancreatectomy.
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J. Clin. Endocrinol. Metab. · Mar 2021
Vitamin D Status in Hospitalized Patients with SARS-CoV-2 Infection.
The role of vitamin D status in COVID-19 patients is a matter of debate. ⋯ 25OHD levels are lower in hospitalized COVID-19 patients than in population-based controls and these patients had a higher prevalence of deficiency. We did not find any relationship between vitamin D concentrations or vitamin deficiency and the severity of the disease.
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J. Clin. Endocrinol. Metab. · Jan 2021
Randomized Controlled TrialDual GIP and GLP-1 Receptor Agonist Tirzepatide Improves Beta-cell Function and Insulin Sensitivity in Type 2 Diabetes.
Novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist (RA) tirzepatide demonstrated substantially greater glucose control and weight loss (WL) compared with selective GLP-1RA dulaglutide. ⋯ Tirzepatide improved markers of IS and beta-cell function to a greater extent than dulaglutide. IS effects of tirzepatide were only partly attributable to WL, suggesting dual receptor agonism confers distinct mechanisms of glycemic control.
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J. Clin. Endocrinol. Metab. · Dec 2020
Systemic Corticosteroids and Mortality in Severe and Critical COVID-19 Patients in Wuhan, China.
Systemic corticosteroids are now recommended in many treatment guidelines, although supporting evidence is limited to 1 randomized controlled clinical trial (RECOVERY). ⋯ Corticosteroid use was not associated with beneficial effect in reducing in-hospital mortality for severe or critical cases in Wuhan. Absence of the beneficial effect in our study in contrast to that observed in the RECOVERY clinical trial may be due to biases in observational data, in particular prescription by indication bias, differences in clinical characteristics of patients, choice of corticosteroid used, timing of initiation of treatment, and duration of treatment.