J Orofac Pain
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To provide a snapshot of the scientific literature on orofacial pain. ⋯ This study complements subject reviews of orofacial pain research and provides a more complete picture of the research activity in this field.
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To describe 1 year's experience in treating orofacial pain with intramuscular injections of 0.5% bupivacaine bilateral to the spinous processes of the lower cervical vertebrae. ⋯ This is the first report of a large case series of emergency department patients whose orofacial pain conditions were treated with intramuscular injections of bupivacaine in the paraspinous muscles of the lower neck. The findings suggest that lower cervical paraspinous intramuscular injections with bupivacaine may prove to be a new therapeutic option for acute orofacial pain in the emergency department setting.
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Randomized Controlled Trial
Effect of peripheral NMDA receptor blockade with ketamine on chronic myofascial pain in temporomandibular disorder patients: a randomized, double-blinded, placebo-controlled trial.
To investigate the effects of local intramuscular injection of the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine on chronic myofascial pain and mandibular function in temporomandibular disorder patients. ⋯ These results suggest that peripheral NMDA receptors do not play a major role in the pathophysiology of chronic myofascial temporomandibular disorder pain. Although there was a minor effect of ketamine on maximum voluntary jaw opening, local administration may not be promising treatment for these patients.
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Randomized Controlled Trial
Nerve growth factor-evoked masseter muscle sensitization and perturbation of jaw motor function in healthy women.
To replicate and extend previous findings of nerve growth factor (NGF)-induced mechanical sensitization in healthy young men to women and test for associations between mechanical sensitization and oral motor function. Combined these data would indicate if injection of NGF into the masseter muscle is a valid model of muscle pain related to temporomandibular disorders (TMD). ⋯ This study shows that injection of NGF into the masseter muscle of women causes local signs of mechanical allodynia and hyperalgesia that persist for at least 7 days as well as pain during strenuous jaw movement. Taking the authors' previous results on NGF effects in men into consideration, these findings lend additional support to the suggestion that this model may serve as a proxy of some of the clinical features of TMD-related muscle pain.
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Randomized Controlled Trial Comparative Study
Short-term effectiveness of a prefabricated occlusal appliance in patients with myofascial pain.
To compare the short-term effectiveness of a stabilization appliance with a prefabricated occlusal appliance in myofascial pain patients in a randomized controlled trial. ⋯ The effectiveness of the prefabricated occlusal appliance seemed to be the same as that of the stabilization appliance. The prefabricated appliance can therefore be recommended as a short-term therapy in adult patients with myofascial pain.