Bmc Cardiovasc Disor
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Bmc Cardiovasc Disor · Oct 2014
BRG1 overexpression in smooth muscle cells promotes the development of thoracic aortic dissection.
Here we investigated Brahma-related gene 1 (BRG1) expression in aortic smooth muscle cells (SMCs) and its role in the regulation of the pathological changes in aortic SMCs of thoracic arotic dissection (TAD). ⋯ BRG1 is significantly upregulated in the aortic SMCs of TAD, and its overexpression might promote the development of TAD by increasing MMP2 and MMP9 expression, inducing SMC apoptosis and the transition from contractile to synthetic phenotype.