Bmc Cardiovasc Disor
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Bmc Cardiovasc Disor · Jul 2014
Observational StudyStatins and the risk of type 2 diabetes mellitus: cohort study using the UK clinical practice pesearch datalink.
There is strong evidence of reductions in major vascular events from statins across all cardiovascular risk categories. However, trials of statin therapy have provided conflicting results regarding statin use and type 2 diabetes (T2DM). We aimed to assess the effect of statins on T2DM development. ⋯ Statin use is associated with an increased risk of T2DM. Our results suggest that the relative risk is higher among people without diagnosed hypertension or cardiovascular disease. These findings should be considered in the context of the observational nature of the data which is prone to bias and unmeasured confounding.