Circ Cardiovasc Qual
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Circ Cardiovasc Qual · Mar 2013
Review Meta AnalysisQuantifying the effect of cardiopulmonary resuscitation quality on cardiac arrest outcome: a systematic review and meta-analysis.
Background- Evidence has accrued that cardiopulmonary resuscitation quality affects cardiac arrest outcome. However, the relative contributions of chest compression components (such as rate and depth) to successful resuscitation remain unclear. Methods and Results- We sought to measure the effect of cardiopulmonary resuscitation quality on cardiac arrest outcome through systematic review and meta-analysis. ⋯ Likewise, survivors were significantly more likely to have received chest compression rates closer to 85 to 100 compressions per minute (cpm) than nonsurvivors (absolute mean difference from 85 cpm, -4.81 cpm; 95% confidence interval, -8.19 to -1.43 [P=0.005]; from 100 cpm, -5.04 cpm; 95% confidence interval, -8.44 to -1.65 [P=0.004]; n=6 studies; I(2)<49%; P for heterogeneity >0.2). No significant difference in no-flow fraction (n=7 studies) or ventilation rate (n=4 studies) was detected between survivors and nonsurvivors. Conclusions- Deeper chest compressions and rates closer to 85 to 100 cpm are significantly associated with improved survival from cardiac arrest.