Circ Cardiovasc Qual
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Circ Cardiovasc Qual · Jul 2013
Review Meta AnalysisComparative tolerability and harms of individual statins: a study-level network meta-analysis of 246 955 participants from 135 randomized, controlled trials.
Our objective was to estimate the comparative harms of individual statins using both placebo-controlled and active-comparator trials. ⋯ As a class, adverse events associated with statin therapy are not common. Statins are not associated with cancer risk but do result in a higher odds of diabetes mellitus. Among individual statins, simvastatin and pravastatin seem safer and more tolerable than other statins.
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Circ Cardiovasc Qual · Jul 2013
Randomized Controlled Trial Multicenter Study Comparative StudyA multicenter, randomized trial of a nurse-led, home-based intervention for optimal secondary cardiac prevention suggests some benefits for men but not for women: the Young at Heart study.
We examined the impact of a prolonged secondary prevention program on recurrent hospitalization in cardiac patients with private health insurance. ⋯ Australian New Zealand Clinical Trials Registry Unique Identifier: 12608000014358. URL: http://www.anzctr.org.au/trial_view.aspx?id=82509.
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Circ Cardiovasc Qual · Jul 2013
Randomized Controlled TrialFeasibility and utility of screening for depression and anxiety disorders in patients with cardiovascular disease.
Depression and anxiety in patients with cardiac disease are common and independently associated with morbidity and mortality. We aimed to explore the use of a 3-step approach to identify inpatients with cardiac disease with depression, generalized anxiety disorder (GAD), or panic disorder; understand the predictive value of individual screening items in identifying these disorders; and assess the relative prevalence of these disorders in this cohort. ⋯ Unique Identifier: NCT01201967. URL: http://www.clinicaltrials.gov/ct2/show/NCT01201967.
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Circ Cardiovasc Qual · Jul 2013
Observational StudyDevelopment and validation of a risk score to predict QT interval prolongation in hospitalized patients.
Identifying hospitalized patients at risk for QT interval prolongation could lead to interventions to reduce the risk of torsades de pointes. Our objective was to develop and validate a risk score for QT prolongation in hospitalized patients. ⋯ A risk score using easily obtainable clinical variables predicts patients at highest risk for QTc interval prolongation and may be useful in guiding monitoring and treatment decisions.
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Circ Cardiovasc Qual · Jul 2013
Hospital strategies associated with 30-day readmission rates for patients with heart failure.
Reducing hospital readmission rates is a national priority; however, evidence about hospital strategies that are associated with lower readmission rates is limited. We sought to identify hospital strategies that were associated with lower readmission rates for patients with heart failure. ⋯ Several strategies were associated with lower hospital RSRRs for patients with heart failure.