Journal of the neurological sciences
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The cerebral distribution of microbleeds in cerebral amyloid angiopathy (CAA) is quite different from that in hypertension, i.e., microbleeds in central gray matters are frequently found in patients with advanced hypertension (aHT), but not in patients with CAA. Distributions within the cortico-subcortical (CSC) area have not been compared between the diseases, and remain poorly understood. ⋯ In this study sample, aHT and CAA show different topographical microbleeds distributions, even in the CSC area. Our results suggest that the CSC microbleeds may reflect different pathophysiological mechanisms between aHT and CAA.