Journal of the neurological sciences
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Meta Analysis Comparative Study
Association of 231G>A polymorphism of endothelin type A receptor gene with migraine: a meta-analysis.
Vascular dysfunction is implied in migraine. Endothelin type A receptor (EDNRA) is a receptor for endothelin-1, a potent vasoconstrictor. Several studies have investigated the association between EDNRA -231G>A SNP and migraine, but showed conflicting results. This study aimed to evaluate the association between EDNRA -231A allele and migraine by meta-analysis. ⋯ This meta-analysis provides evidence suggesting a significant association between EDNRA -231G>A polymorphism and migraine.