Journal of the neurological sciences
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Elevated intracranial pressure (ICP) is generally observed in brain injury and intracerebral hemorrhage (ICH) patients and is consistently associated with poor neurological outcome. Intracranial pressure variability (IPV) is a better predictor of long-term neurological outcome than mean ICP in traumatic brain injury patients. However, whether IPV regulates functional outcome in ICH patients has not been investigated. In the present study, we investigated the relationship between IPV and functional outcome in ICH patients and determined whether IPV is a valid predictor of neurological outcome in ICH patients. ⋯ The results suggest that high IPV is correlated with poorer outcome in ICH patients. Managing the ICP at an appropriate level during the early phase after ICH may improve functional outcome in ICH patients.