Ginekol Pol
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Recent studies suggest that preterm delivery might be conditioned genetically. The main aim of this study was to examine the relationship between spontaneous preterm delivery (PTD) and the carriage of polymorphic genes that code the following cytokines: interleukin-1beta [IL1beta (+3953C>T)], interleukin-6 promoter [IL6 (-174G>C)], tumour necrosis factor-alpha promoter [TNFalpha (-308G>A)] and interleukin-1 receptor antagonist (IL1RN) in the population of Polish women. ⋯ Maternal carriage of the IL1RN*2 allele appears to be associated with an elevated risk of preterm delivery in the population of Polish women. Coincidence of IL1RN*2 with at least one copy of IL-6 allele G might increase the risk of preterm delivery even further.