Ginekol Pol
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Increasing evidence indicates that genetic factors are involved in the process of carcinogenesis. BRCA 1 mutation has been proven to be responsible for increased risk of ovarian cancer However the importance of other genetic disorders, such as MTHFR polymorphism for increased risk of carcinogenesis, is still to be determined. Abnormal methylation seems to play a significant role in ovarian cancer pathogenesis. MTHFR catalyses the conversion of 5,10-methylenetetrahydrofolate into 5-methyltetrahydrofolate which is a co-substrate in homocysteine remethylation into methionine. Thermolabile MTHFR protein variants with lower enzymatic activity are the effects of the mutation. ⋯ Contrary to numerous suggestions in various publications, we did not confirm the correlation between MTHFR 677C>T polymorphism and the influence on the risk of ovarian cancer in BRCA1 mutation carriers in the investigated group of Polish women.
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Obstetric hemorrhage is a life-threatening situation for every mother and child. NovoSeven is a recombinant, activated factor VII which may be useful in the treatment of uncontrollable hemorrhage. It accelerates hemostasis by direct activation of the factor X. ⋯ NovoSeven is a very effective agent in the treatment of postpartum hemorrhage.