The Journal of pediatrics
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The Journal of pediatrics · Nov 1995
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialDiscontinuing penicillin prophylaxis in children with sickle cell anemia. Prophylactic Penicillin Study II.
To evaluate the consequences of discontinuing penicillin prophylaxis at 5 years of age in children with sickle cell anemia who had received prophylactic penicillin for much of their lives. ⋯ Children with sickle cell anemia who have not had a prior severe pneumococcal infection or a splenectomy and are receiving comprehensive care may safely stop prophylactic penicillin therapy at 5 years of age. Parents must be aggressively counseled to seek medical attention for all febrile events in children with sickle cell anemia.
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The Journal of pediatrics · Nov 1995
Comparative StudyHemodynamic prediction of complications in neonatal respiratory distress syndrome.
We hypothesized that the absence of an increase in the Doppler-derived aortopulmonary pressure gradient (APPG) across the ductus arteriosus, which reflects pulmonary artery pressure during the first day of life, can predict clinical complications in preterm infants with neonatal respiratory distress syndrome (RDS) STUDY DESIGN: Twenty-nine healthy preterm infants weighing 2210 +/- 244 gm (mean +/- SEM) and 63 infants with RDS weighing 1645 +/- 86 gm were studied with the Doppler ultrasound technique for measurement of the mean APPG at 2, 24, 48, and 72 hours of age. Of infants with RDS, 67% were treated with synthetic surfactant. ⋯ Noninvasive measurement of the change in APPG during the first day of life may provide a useful method for identifying infants with RDS at high risk of neonatal complications.
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The Journal of pediatrics · Nov 1995
Review Case ReportsFavism in a female newborn infant whose mother ingested fava beans before delivery.
We describe a case of favism in a female newborn infant with glucose-6-phosphate dehydrogenase (G6PD) deficiency whose mother had ingested fava beans 5 days before delivery. At birth there were clinical and hematologic signs of hemolytic anemia, hemoglobinuria, and no blood group immunization. Study of the G6PD activity and 2-deoxy-glucose-6-phosphate utilization rate revealed that the infant and the mother were heterozygous for G6PD deficiency.
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The Journal of pediatrics · Nov 1995
Comparative StudyNeurocognitive deficits in morbidly obese children with obstructive sleep apnea.
Neurocognitive abilities were measured in 14 morbidly obese children, five of whom had obstructive sleep apnea as determined by polysomnography. As in adults, children with obstructive sleep apnea had deficits in learning, memory, and vocabulary. Moreover, apneic/hypopneic events were inversely related to memory and learning performance among the entire sample.
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The Journal of pediatrics · Nov 1995
Early echocardiographic prediction of symptomatic patent ductus arteriosus in preterm infants undergoing mechanical ventilation.
To identify early echocardiographic markers allowing prediction of subsequent symptomatic patent ductus arteriosus (PDA). ⋯ Color Doppler measurement of the internal ductal diameter allows early prediction of significant PDA in preterm infants.