The Journal of pediatrics
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The Journal of pediatrics · Mar 1999
Clinical TrialTransdermal fentanyl in children with cancer pain: feasibility, tolerability, and pharmacokinetic correlates.
(1) To assess the feasibility and tolerability of the therapeutic transdermal fentanyl system (TTS-fentanyl) by using a clinical protocol developed for children with cancer pain. (2) To estimate the pediatric pharmacokinetic parameters of TTS-fentanyl. ⋯ Treatment of children with TTS-fentanyl is feasible and well tolerated and yields fentanyl pharmacokinetic parameter estimates similar to those for adults. A larger study is required to confirm these findings and further test the clinical protocol.