The Journal of pediatrics
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The Journal of pediatrics · Apr 2003
Randomized Controlled Trial Clinical TrialMidazolam syrup as a premedication to reduce the discomfort associated with pediatric intravenous catheter insertion.
This randomized, double-blind, placebo-controlled study evaluated midazolam syrup for reducing discomfort from intravenous placement in children 9 months to 6 years. Parents and observers rated the child's discomfort by using visual analogue scales. Median parents' pain scores were significantly lower in the midazolam than the placebo group (P =.002). Midazolam effectively reduces discomfort associated with intravenous insertion.
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The Journal of pediatrics · Apr 2003
Comparative StudyRapid increase of morphine and benzodiazepine usage in the last three days of life in children with cancer is related to neuropathic pain.
To test the hypothesis that children with terminal cancer and neuropathic pain require rapid increases of opioids and benzodiazepines immediately before death, we compared drug usage in the last 72 hours of life in children with and without neuropathic pain. ⋯ Dying children with cancer and neuropathic pain have higher baseline requirements of morphine and benzodiazepines and require rapid increases of both drugs in the last 72 hours of life than dying children without neuropathic pain.