The Journal of pediatrics
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The Journal of pediatrics · Nov 2009
Comparative Study Clinical TrialAutomated adjustment of inspired oxygen in preterm infants with frequent fluctuations in oxygenation: a pilot clinical trial.
To assess the efficacy of a system for automated fraction of inspired oxygen (FiO(2)) adjustment in maintaining oxygen saturation (SpO(2)) within an intended range in preterm infants with spontaneous fluctuations in SpO(2). ⋯ Automated FiO(2) adjustment improved maintenance of SpO(2) within the intended range and reduced hyperoxemia and FiO(2). These findings should be examined in longer periods with standard clinical conditions and, eventually, in the context of randomized trials powered to detect clinically important effects on outcome.
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The Journal of pediatrics · Nov 2009
Bronchiectasis in infants and preschool children diagnosed with cystic fibrosis after newborn screening.
To determine the prevalence of bronchiectasis in young children with cystic fibrosis (CF) diagnosed after newborn screening (NBS) and the relationship of bronchiectasis to pulmonary inflammation and infection. ⋯ Pulmonary abnormalities are common in infants and young children with CF and relate to neutrophilic inflammation and infection with P. aeruginosa. Current models of care for infants with CF fail to prevent respiratory sequelae. Bronchiectasis is a clinically relevant endpoint that could be used for intervention trials that commence soon after CF is diagnosed after NBS.
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The Journal of pediatrics · Nov 2009
Pediatric critical illness hyperglycemia: risk factors associated with development and severity of hyperglycemia in critically ill children.
To determine which children are susceptible to critical illness hyperglycemia (CIH) and whether CIH severity and duration correlate with diagnosis or illness severity. ⋯ CIH severity and duration correlate with diagnosis and illness severity. Certain "risk factors" may be predictive of who develops CIH.