The Journal of pediatrics
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The Journal of pediatrics · Sep 2011
Comparative StudyLongitudinal assessment of hemoglobin oxygen saturation in preterm and term infants in the first six months of life.
To report longitudinal home recordings of hemoglobin O(2) saturation by pulse oximetry (Spo(2)) during unperturbed sleep in preterm and term infants. ⋯ Clinically inapparent intermittent hypoxemia occurs in epochs unperturbed by and temporally unrelated to apnea or bradycardia events, especially in preterm infants at 36 to 44 weeks PMA.
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The Journal of pediatrics · Sep 2011
Diagnostic value of nasal nitric oxide measured with non-velum closure techniques for children with primary ciliary dyskinesia.
Nasal nitric oxide (nNO) is a reliable non-invasive screening test for primary ciliary dyskinesia (PCD), but the recommended technique, exhalation against resistance (ER), requires cooperation limiting its use in young children. Our objectives were to determine whether easier non-velum closure techniques have the ability to discriminate PCD and longitudinal reproducibility. ⋯ Non-velum closure techniques are reproducible and valid to discriminate PCD; however, they generally yield lower values than ER.
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The Journal of pediatrics · Sep 2011
Central nervous system events in children with sickle cell disease presenting acutely with headache.
To determine the frequency of acute care visits and risk factors for central nervous system (CNS) events in children with homozygous sickle cell disease (SCD-SS) with an acute headache. ⋯ Acute headache is common in pediatric SCD-SS and more frequently associated with acute CNS events than in the general pediatric population. A history of stroke, transient ischemic attack, seizures, neurologic symptoms, focal neurologic exam, or elevated platelet counts at presentation warrant confirmatory imaging studies. Whether a more limited workup is adequate for other children should be confirmed in a larger, prospective study.
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The Journal of pediatrics · Sep 2011
Randomized Controlled TrialInhaled beta-2 agonist salbutamol for the treatment of transient tachypnea of the newborn.
To evaluate the efficacy of inhaled salbutamol, a beta-2 adrenergic agonist, for the treatment of transient tachypnea of the newborn (TTN) and to determine whether inhaled salbutamol is safe in newborn infants. ⋯ Inhaled salbutamol treatment was effective with respect to both clinical and laboratory findings of TTN and without adverse events.
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The Journal of pediatrics · Sep 2011
Comparative StudyPopulation pharmacokinetics of pentobarbital in neonates, infants, and children after open heart surgery.
To determine the pharmacokinetics of pentobarbital in neonates, infants, and young children with congenital heart disease after open-heart surgery. ⋯ Pentobarbital pharmacokinetics is influenced by age and weight. Subjects with single-ventricle physiology demonstrated a 15% decrease in clearance when compared with subjects with two-ventricle physiology.