The Journal of pediatrics
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The Journal of pediatrics · Sep 2011
Randomized Controlled TrialInhaled beta-2 agonist salbutamol for the treatment of transient tachypnea of the newborn.
To evaluate the efficacy of inhaled salbutamol, a beta-2 adrenergic agonist, for the treatment of transient tachypnea of the newborn (TTN) and to determine whether inhaled salbutamol is safe in newborn infants. ⋯ Inhaled salbutamol treatment was effective with respect to both clinical and laboratory findings of TTN and without adverse events.
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The Journal of pediatrics · Sep 2011
Comparative StudyLongitudinal assessment of hemoglobin oxygen saturation in preterm and term infants in the first six months of life.
To report longitudinal home recordings of hemoglobin O(2) saturation by pulse oximetry (Spo(2)) during unperturbed sleep in preterm and term infants. ⋯ Clinically inapparent intermittent hypoxemia occurs in epochs unperturbed by and temporally unrelated to apnea or bradycardia events, especially in preterm infants at 36 to 44 weeks PMA.
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The Journal of pediatrics · Sep 2011
Comparative StudyPopulation pharmacokinetics of pentobarbital in neonates, infants, and children after open heart surgery.
To determine the pharmacokinetics of pentobarbital in neonates, infants, and young children with congenital heart disease after open-heart surgery. ⋯ Pentobarbital pharmacokinetics is influenced by age and weight. Subjects with single-ventricle physiology demonstrated a 15% decrease in clearance when compared with subjects with two-ventricle physiology.
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The Journal of pediatrics · Sep 2011
Central nervous system events in children with sickle cell disease presenting acutely with headache.
To determine the frequency of acute care visits and risk factors for central nervous system (CNS) events in children with homozygous sickle cell disease (SCD-SS) with an acute headache. ⋯ Acute headache is common in pediatric SCD-SS and more frequently associated with acute CNS events than in the general pediatric population. A history of stroke, transient ischemic attack, seizures, neurologic symptoms, focal neurologic exam, or elevated platelet counts at presentation warrant confirmatory imaging studies. Whether a more limited workup is adequate for other children should be confirmed in a larger, prospective study.