The Journal of pediatrics
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The Journal of pediatrics · Apr 2012
Multicenter StudyPharmacokinetics of intravenous lorazepam in pediatric patients with and without status epilepticus.
To evaluate the single dose pharmacokinetics of an intravenous dose of lorazepam in pediatric patients treated for status epilepticus (SE) or with a history of SE. ⋯ Lorazepam pharmacokinetics in convulsive SE is similar to earlier pharmacokinetics measured in pediatric patients with cancer, except for longer half-life, and similar to adult pharmacokinetics parameters except for increased clearance.
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The Journal of pediatrics · Apr 2012
Randomized Controlled Trial Multicenter StudyEvolution of encephalopathy during whole body hypothermia for neonatal hypoxic-ischemic encephalopathy.
To examine the predictive ability of stage of hypoxic-ischemic encephalopathy (HIE) for death or moderate/severe disability at 18 months among neonates undergoing hypothermia. ⋯ On serial neurologic examinations, improvement in stage of HIE was associated with cooling. Persistence of severe HIE at 72 hours and an abnormal neurologic exam at discharge were associated with a greater risk of death or disability.