The Journal of pediatrics
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The Journal of pediatrics · Jul 2014
Randomized Controlled TrialRandomized controlled trial of oxygen saturation targets in very preterm infants: two year outcomes.
To assess whether an oxygen saturation (Spo2) target of 85%-89% compared with 91%-95% reduced the incidence of the composite outcome of death or major disability at 2 years of age in infants born at <28 weeks' gestation. ⋯ Although there was no benefit or harm from targeting a lower compared with a higher saturation in this trial, further information will become available from the prospectively planned meta-analysis of this and 4 other trials comprising a total of nearly 5000 infants.
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The Journal of pediatrics · Jul 2014
Review Meta AnalysisHypotonic versus isotonic fluids in hospitalized children: a systematic review and meta-analysis.
To determine whether the use of hypotonic vs isotonic maintenance fluids confers an increased risk of hyponatremia in hospitalized children. ⋯ In hospitalized children in intensive care and postoperative settings, the administration of hypotonic maintenance fluids increases the risk of hyponatremia when compared with administration of isotonic fluids. For patients on general wards, insufficient data are available based on the reviewed studies, and individual risk factors must be assessed.
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The Journal of pediatrics · Jul 2014
A population-based study of childhood respiratory morbidity after severe lower respiratory tract infections in early childhood.
To estimate the risk of childhood chronic respiratory morbidity among those hospitalized for severe lower respiratory tract infection (LRTI) in early childhood, and to determine whether severe LRTI is an independent predictor. ⋯ Hospitalization of young children for LRTIs is associated with two-fold increased risk of childhood chronic respiratory morbidity, demonstrating the ongoing impact of LRTI in infancy.
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The Journal of pediatrics · Jul 2014
Randomized Controlled TrialBotulinum toxin A for nonambulatory children with cerebral palsy: a double blind randomized controlled trial.
To examine the efficacy and safety of intramuscular botulinum toxin A (BoNT-A) to reduce spasticity and improve comfort and ease of care in nonambulant children with cerebral palsy (CP). ⋯ In a double-blind randomized sham-controlled trial, intramuscular BoNT-A and therapy were effective for improving ease of care and comfort for nonambulant children with CP. There was no increase in moderate and severe AE in the children who had BoNT-A injections compared with the sham group.