The Journal of pediatrics
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The Journal of pediatrics · Apr 2012
Multicenter StudyPharmacokinetics of intravenous lorazepam in pediatric patients with and without status epilepticus.
To evaluate the single dose pharmacokinetics of an intravenous dose of lorazepam in pediatric patients treated for status epilepticus (SE) or with a history of SE. ⋯ Lorazepam pharmacokinetics in convulsive SE is similar to earlier pharmacokinetics measured in pediatric patients with cancer, except for longer half-life, and similar to adult pharmacokinetics parameters except for increased clearance.
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The Journal of pediatrics · Apr 2012
Randomized Controlled Trial Multicenter StudyEvolution of encephalopathy during whole body hypothermia for neonatal hypoxic-ischemic encephalopathy.
To examine the predictive ability of stage of hypoxic-ischemic encephalopathy (HIE) for death or moderate/severe disability at 18 months among neonates undergoing hypothermia. ⋯ On serial neurologic examinations, improvement in stage of HIE was associated with cooling. Persistence of severe HIE at 72 hours and an abnormal neurologic exam at discharge were associated with a greater risk of death or disability.
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The Journal of pediatrics · Mar 2012
Randomized Controlled TrialRespiratory function monitor guidance of mask ventilation in the delivery room: a feasibility study.
To investigate whether using a respiratory function monitor (RFM) during mask resuscitation of preterm infants reduces face mask leak and improves tidal volume (V(T)). ⋯ Using an RFM was associated with significantly less mask leak, more mask adjustments, and a lower rate of excessive V(T).
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The Journal of pediatrics · Mar 2012
ReviewAccuracy and precision of the signs and symptoms of streptococcal pharyngitis in children: a systematic review.
To conduct a systematic review to determine whether clinical findings can be used to rule in or to rule out streptococcal pharyngitis in children. ⋯ Symptoms and signs, either individually or combined into prediction rules, cannot be used to definitively diagnose or rule out streptococcal pharyngitis.
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The Journal of pediatrics · Feb 2012
Multicenter StudyCoagulopathy is prevalent and associated with adverse outcomes in transfused pediatric trauma patients.
To evaluate coagulopathy in pediatric trauma patients on presentation to the emergency department, and to quantify the relationship with mortality. ⋯ Coagulopathy is prevalent in pediatric trauma patients ill enough to require a transfusion and is strongly associated with mortality. Studies are needed to determine whether early coagulation factor replacement and the institution of massive transfusion protocols may improve outcomes in these patients.