The Journal of pediatrics
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The Journal of pediatrics · Jan 2003
Effect of cardiopulmonary bypass on urea cycle intermediates and nitric oxide levels after congenital heart surgery.
To test the hypothesis that cardiopulmonary bypass used for repair of ventricular septal defects and atrioventricular septal defects would decrease availability of urea cycle intermediates including arginine and subsequent nitric oxide availability. ⋯ Cardiopulmonary bypass significantly decreases availability of arginine, citrulline, and nitric oxide metabolites in the postoperative period. Decreased availability of nitric oxide precursors may contribute to the increased risk of postoperative pulmonary hypertension.
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The Journal of pediatrics · Dec 2002
Inhaled prostacyclin for term infants with persistent pulmonary hypertension refractory to inhaled nitric oxide.
We report the use of inhaled prostacyclin (PGI(2)) in 4 neonates with persistent pulmonary hypertension and hypoxemia refractory to inhaled nitric oxide. Oxygenation rapidly improved after inhalation of PGI(2) in all infants. The condition of one infant subsequently deteriorated, and alveolar capillary dysplasia was found at autopsy. The surviving infants were discharged with normal oxygen saturations in room air.
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The Journal of pediatrics · Nov 2002
Randomized Controlled Trial Comparative Study Clinical TrialEfficacy of zinc-fortified oral rehydration solution in 6- to 35-month-old children with acute diarrhea.
To determine the efficacy of zinc-fortified oral rehydration salts solution (ORS) in comparison to ORS without zinc in 6- to 35-month-old urban children with acute diarrhea not sick enough to be hospitalized. ⋯ Zinc-ORS was moderately efficacious in reducing the severity of acute diarrhea without increasing vomiting or reducing ORS intake.
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The Journal of pediatrics · Oct 2002
Comparative StudyDevelopment of a pediatric age- and disease-specific severity measure.
To adapt the adult Comprehensive Severity Index (CSI) for hospitalized pediatric patients and evaluate the ability of the CSI to predict common outcomes. ⋯ The age- and disease-specific pediatric CSI score correlates highly with LOS, cost, and mortality in hospitalized children and can help determine the best clinical practices for specific diseases and adjust for differences in severity of illness across providers.