The Journal of pediatrics
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The Journal of pediatrics · Dec 2001
Randomized Controlled Trial Multicenter Study Clinical TrialA two-year randomized, placebo-controlled trial of dornase alfa in young patients with cystic fibrosis with mild lung function abnormalities.
Our objective was to determine whether long-term treatment of young patients with cystic fibrosis (CF) with dornase alfa maintains lung function and reduces respiratory tract exacerbations. ⋯ Treatment of young patients with CF with dornase alfa maintains lung function and reduces the risk of exacerbations over a 96-week period.
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The Journal of pediatrics · Oct 2001
Clinical TrialDouble catheter technique for misdirected umbilical vein catheter.
We studied the success rate of the double catheter technique during umbilical vein catheter placement in 42 patients with a misdirected umbilical vein catheter. The misdirected catheter was left in place, and an additional catheter was inserted. X-ray films confirmed that successful placement was achieved in 50% of infants without significant adverse effects.
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The Journal of pediatrics · Sep 2001
Clinical TrialSerum ionized magnesium in post-traumatic headaches.
The objective of this study was to determine the values of serum ionized magnesium, total magnesium, and ionized calcium/ionized magnesium ratios in children with headaches. One hundred thirty-five children with primary complaints of headaches were classified according to the criteria of the International Headache Society. Blood samples were obtained and tested for ionized magnesium (IMg(2+)), total magnesium, ionized calcium (ICa(2+)), and pH. ⋯ Nine children were given a diagnosis of post-traumatic headache. Six of them had statistically significant (P <.05) lowered IMg(2+) levels and high ICa(2+)/IMg(2+) ratios. Abnormalities in serum IMg(2+) concentrations and ICa(2+)/IMg(2+) ratios were found in children with post-traumatic headaches, but total magnesium levels were normal.
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The Journal of pediatrics · Sep 2001
Efficacy and optimal dose of daily polyethylene glycol 3350 for treatment of constipation and encopresis in children.
To determine efficacy, safety, and optimal dose of a laxative, polyethylene glycol (PEG) 3350, in children with chronic constipation. ⋯ Daily administration of PEG at a mean dose of 0.8 g/kg is an effective, safe, and palatable treatment for constipation.