The Journal of pediatrics
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The Journal of pediatrics · Aug 2014
Multicenter StudyHypothermia therapy for neonatal hypoxic ischemic encephalopathy in the state of California.
To characterize the implementation of hypothermia for neonatal hypoxic ischemic encephalopathy (HIE) in a population-based cohort. ⋯ Our findings highlight an opportunity to explore practice-site variation and to develop quality improvement interventions to assure consistent evidence-based care of term infants with HIE and appropriate application of hypothermia therapy for eligible newborns.
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The Journal of pediatrics · Aug 2014
Randomized Controlled Trial Multicenter StudyRespiratory outcomes of the surfactant positive pressure and oximetry randomized trial (SUPPORT).
To explore the early childhood pulmonary outcomes of infants who participated in the National Institute of Child Health and Human Development's Surfactant Positive Airway Pressure and Pulse Oximetry Randomized Trial (SUPPORT), using a factorial design that randomized extremely preterm infants to lower vs higher oxygen saturation targets and delivery room continuous positive airway pressure (CPAP) vs intubation/surfactant. ⋯ Treatment with early CPAP rather than intubation/surfactant is associated with less respiratory morbidity by 18-22 months CA. Longitudinal assessment of pulmonary morbidity is necessary to fully evaluate the potential benefits of respiratory interventions for neonates.
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The Journal of pediatrics · Aug 2014
Randomized Controlled Trial Multicenter StudyTotal body polyethylene wraps for preventing hypothermia in preterm infants: a randomized trial.
To evaluate whether a polyethylene total body wrapping (covering both the body and head) is more effective than conventional treatment (covering up to the shoulders) in reducing perinatal thermal losses in very preterm infants. ⋯ Total body wrapping is comparable with covering the body up to the shoulders in preventing postnatal thermal losses in very preterm infants.
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The Journal of pediatrics · Aug 2014
Randomized Controlled TrialSchool-age outcomes following a randomized controlled trial of magnesium sulfate for neuroprotection of preterm infants.
In a French randomized trial, children at school-age demonstrated no evidence of harm from fetal exposure to MgSO4 before very preterm birth. Motor dysfunction/death, qualitative behavioral disorders, cognitive difficulties, school grade repetition, and education services were decreased in the children exposed to MgSO4, although the differences were not significant.