The Journal of pediatrics
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The Journal of pediatrics · Jun 2014
Randomized Controlled Trial Comparative StudyResuscitation of preterm infants with different inspired oxygen fractions.
To test the hypothesis that an initial fraction of inspired oxygen (FiO2) of 30% during resuscitation of preterm infants results in less oxidative stress and is associated with improved clinical outcomes compared with an FiO2 of 65%. ⋯ Initial supplementation of preterm infants with 30% oxygen during the fetal-to-neonatal transition is as safe as 65% oxygen, with no differences in oxidative stress markers or BPD.
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The Journal of pediatrics · Jun 2014
Randomized Controlled Trial Comparative StudyAntibody persistence and booster response of a quadrivalent meningococcal conjugate vaccine in adolescents.
To evaluate the tolerability and immunogenicity of a booster dose of the quadrivalent meningococcal conjugate vaccine MenACWY-CRM (Menveo, Novartis Vaccines and Diagnostics, Siena, Italy) administered 3 years after primary vaccination of adolescents enrolled in a phase 3 study with either MenACWY-CRM or MenACWY-D (Menactra, Sanofi Pasteur, Swiftwater, Pennsylvania). ⋯ MenACWY-CRM can be used to boost adolescents who have received a primary vaccination with either MenACWY-CRM or MenACWY-D.
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The Journal of pediatrics · May 2014
Randomized Controlled Trial Comparative StudyTidal breathing in preterm infants receiving and weaning from continuous positive airway pressure.
To compare tidal breathing on different continuous positive airway pressure (CPAP) devices and pressures and to serially measure tidal breathing during weaning off CPAP using electromagnetic inductive plethysmography. ⋯ At different pressure settings, on all CPAP devices the measured MV/kg was similar either through increasing VT/kg and decreasing fR (nCPAP and nBiPAP) or maintaining both (bCPAP). Serial tidal breathing measurements may aid weaning from CPAP.
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The Journal of pediatrics · May 2014
Randomized Controlled Trial Comparative StudyRemifentanil versus morphine-midazolam premedication on the quality of endotracheal intubation in neonates: a noninferiority randomized trial.
To compare remifentanil and morphine-midazolam for use in nonurgent endotracheal intubation in neonates. ⋯ In our cohort, remifentanil was at least as effective as the morphine-midazolam regimen for endotracheal intubation. Thus, premedication using this very-short-acting opioid can be considered in urgent intubations and is advantageous in rapid extubation.
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The Journal of pediatrics · May 2014
Randomized Controlled TrialThe effects of umbilical cord milking on hemodynamics and neonatal outcomes in premature neonates.
To determine whether umbilical cord milking (UCM) improves systemic blood flow and reduces neonatal morbidities compared with immediate cord clamping (ICC). ⋯ We demonstrate greater systemic blood flow with UCM in preterm neonates compared with ICC. Future large prospective trials are needed to determine whether UCM reduces intraventricular hemorrhage and other long-term morbidities.