Bmc Med Res Methodol
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Bmc Med Res Methodol · Apr 2017
Impact of correlation of predictors on discrimination of risk models in development and external populations.
The area under the ROC curve (AUC) of risk models is known to be influenced by differences in case-mix and effect size of predictors. The impact of heterogeneity in correlation among predictors has however been under investigated. We sought to evaluate how correlation among predictors affects the AUC in development and external populations. ⋯ Discrimination of risk prediction models should be assessed in various external populations with different correlation structures to make better inferences about model generalizability.