Bmc Med Res Methodol
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Bmc Med Res Methodol · Jan 2020
Comparative StudyComparison of Bayesian and frequentist group-sequential clinical trial designs.
There is a growing interest in the use of Bayesian adaptive designs in late-phase clinical trials. This includes the use of stopping rules based on Bayesian analyses in which the frequentist type I error rate is controlled as in frequentist group-sequential designs. ⋯ Comparison of frequentist and Bayesian designs can encourage careful thought about design parameters and help to ensure appropriate design choices are made.