Health Qual Life Out
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Health Qual Life Out · Jan 2015
Randomized Controlled TrialEffect of ivacaftor treatment in patients with cystic fibrosis and the G551D-CFTR mutation: patient-reported outcomes in the STRIVE randomized, controlled trial.
Cystic fibrosis (CF) is an inherited, rare autosomal recessive disease that results in chronically debilitating morbidities and high premature mortality. We evaluated how ivacaftor treatment affected CF symptoms, functioning, and well-being, as measured by the Cystic Fibrosis Questionnaire-Revised (CFQ-R), a widely-used patient-reported outcome (PRO) measure. ⋯ Results illustrate broad benefits of ivacaftor treatment across many domains: respiratory symptoms, physical and social functioning, health perceptions, and vitality, as measured by the CFQ-R. The breadth of improvements reflects the systemic mechanism of action of ivacaftor compared to other therapies. Findings support the patient-reported value of ivacaftor treatment in this patient population.
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Health Qual Life Out · Jan 2015
Validation of the Dutch Aging Perceptions Questionnaire and development of a short version.
Perceptions of aging have been found to independently contribute to various aspects of health and wellbeing in old age. Since valid and reliable perceptions of aging instruments are unavailable in Dutch, these associations have not yet been tested in the Netherlands. This study examined the reliability and construct validity of the Dutch-language version of the 7-dimension Aging Perceptions Questionnaire (APQ). Furthermore, in order to decrease the response burden, while retaining the APQ's original factor structure, a short version of the APQ (APQ-S) was developed as an alternative to the 5-dimension Brief APQ (B-APQ). ⋯ With its multidimensional nature and acceptable psychometric properties, the Dutch language version of the APQ may prove to be an invaluable instrument to assess the seven perceptions of aging dimensions among older populations for geriatric research. However, use of a shortened version is advised, as these are less labor intensive and areas of localized strain are addressed. The choice between the APQ-S and the B-APQ should be based on theoretical and practical considerations concerning the dimensional structure most suitable for the study.
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Health Qual Life Out · Jan 2015
Comparative StudyConfirmatory factor analysis of the Korean version of the short-form McGill pain questionnaire with chronic pain patients: a comparison of alternative models.
The Short Form of the McGill Pain Questionnaire (SF-MPQ) is the most widely used assessment of the quality and intensity of pain. In previous validation studies, the factor structure of the SF-MPQ varied widely from various two-factor structures to a five-factor structure, although research on the SF-MPQ quite consistently supports its two-factor structure (i.e., sensory and affective) across different countries and languages. In Korea, the results of exploratory factor analysis of a Korea version of SF-MPQ (KSF-MPQ) showed 2-factor structure consisting of 'sensory' and 'affective' excluding two items such as splitting and heavy. As an attempt to further validate the KSF-MPQ, the purpose of this study was to confirm whether the KSF-MPQ model is an appropriate model for chronic pain patients in Korea by comparing several alternative models of the SF-MPQ. ⋯ The results showed the KSF-MPQ is cross-culturally equivalent to the original questionnaire. Thus, the KSF-MPQ is valid measurement for assessing the quality and intensity of pain to chronic pain patients and may be helpful in clinical and research settings in Korea.