Life sciences
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Pulmonary hypertension due to left heart failure (PH-LHF) is the most common cause of pulmonary hypertension. However, therapies for PH-LHF are lacking. Therefore, we investigated the effects and potential mechanism of dehydroepiandrosterone (DHEA) treatment in an experimental model of PH-LHF. ⋯ DHEA not only prevents the development of PH-LHF and RV failure but also rescues severe preexisting PH-LHF.