Biological psychology
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Biological psychology · Dec 2010
Randomized Controlled TrialNeurocognitive effects of HF-rTMS over the dorsolateral prefrontal cortex on the attentional processing of emotional information in healthy women: an event-related fMRI study.
Current evidence concerning the neurocircuitry underlying the interplay between attention and emotion is mainly correlational. We used high-frequency repetitive Transcranial Magnetic Stimulation (HF-rTMS) to experimentally manipulate activity within the right or left dorsolateral prefrontal cortex (DLPFC) of healthy women and examined changes in attentional processing of emotional information using an emotional modification of the exogenous cueing task during event-related fMRI. ⋯ Left prefrontal HF-rTMS resulted in diminished attentional engagement by angry faces and was associated with increased activity within the right DLPFC, dACC, right superior parietal gyrus and left orbitofrontal cortex. The present observations are in line with reports of a functionally interactive network of cortical-limbic pathways that play a central role in emotion regulation.
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Biological psychology · Dec 2010
Comparative StudyExposure to the context and removing the unpredictability of the US: two methods to reduce contextual anxiety compared.
Chronic anxiety may differ from cued fear and hence require other treatment strategies. In a human fear conditioning paradigm, chronic anxiety to the experimental context was experimentally induced by presenting unpredictable shocks. Two methods to reduce chronic anxiety were tested and compared. ⋯ A control group continued to receive unsignaled shocks. Results indicated that chronic contextual anxiety, as measured by fear-potentiated startle and US-expectancy ratings, was equally reduced in the context-exposure group as in the signaled group compared with the control group. When applied to the treatment of, for example, panic disorder, these findings support the idea that exposure to the context in which the unpredictable panic attacks occurred and making unpredictable panic attacks predictable, are both valuable methods in order to reduce chronic anxiety.