Genet Mol Res
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Obesity is due to the combined effects of genes, environment, lifestyle, and the interactions of these factors. The adrenergic receptor beta3 (beta3-AR), leptin (LEP) and leptin receptor (LEPR) genes have been intensively evaluated in the search of variants that could be related to obesity and its cardiometabolic complications. The results of most of these studies have been controversial. ⋯ Q223R variant being related to BMI increase. The haplotype combination of LEP c.-2548G>A and LEPR p. Q223R variants was related to a 58% increase in obesity risk.