Eur Rev Med Pharmaco
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Eur Rev Med Pharmaco · Aug 2013
Review Comparative StudySafety and efficacy of the combination acetaminophen-codeine in the treatment of pain of different origin.
Pain is the most common reason people see doctors in developed Countries and a very common cause of access in Emergency Department (ED). The combination acetaminophen/codeine represents the standard medication in the second step of the WHO analgesic scale and codeine is one of the most commonly used opioid analgesic for a variety of pain conditions. However, many aspects related to safety and efficacy are still undefined. ⋯ Acetaminophen/codeine combination is effective in the treatment of pain, through a synergistic action of the two molecules, and is not inferior to NSAIDs. Side effects of acetaminophen/codeine are usually minor, differently from NSAIDs, which may induce some potentially life threatening conditions.
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Eur Rev Med Pharmaco · Aug 2013
Late presentation of HIV infection: predictors of delayed diagnosis and survival in Eastern Sicily.
Across Europe, more than one third of patients are diagnosed with HIV infection late. Late presentation for care has been associated with higher risk of clinical progression and mortality. In the present study, we evaluated the prevalence, epidemiological characteristics and survival probability of patients with late and very late presentation, newly diagnosed with HIV infection in Catania, Italy, from 1985 to 2010. ⋯ More than fifty percent of patients in our setting were diagnosed late with HIV infection and, consequently, treated late. Late and very late presentation were associated with lower survival probability. The implementation of strategies focused on targeted prevention efforts and HIV testing programs appears fundamental to diagnose and treat HIV infection as early as possible.
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Eur Rev Med Pharmaco · Aug 2013
Double plating for the treatment of distal tibia and fibula fractures: case series of twenty five patients.
The treatment of fractures of the distal third of the tibia and fibula usually involves two incisions, thus raising the risk of wound dehiscence, wound necrosis, infection, and the delayed union or non-union of distal tibial fractures. To decrease and prevent aforementioned serious complications, one-incision double-plating technique was advocated here. ⋯ One-incision double-plating is a safe and effective alternative for treatment of distal tibia and fibula fractures.