Int J Clin Pharm Th
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This review evaluates the effect of obesity on the various isozymes of the cytochrome P450 enzyme system. ⋯ The effect of obesity on CYP450 appears to be isozyme-specific with the activity of cytochrome P450 3A4 decreasing and that of cytochrome P450 2E1 increasing. The effect of obesity on the cytochrome P450 1A2, 2C9, 2C19, and 2D6 isozymes is inconclusive.