Int J Clin Pharm Th
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Int J Clin Pharm Th · Oct 1999
Randomized Controlled Trial Comparative Study Clinical TrialAddition of intrathecal midazolam to bupivacaine produces better post-operative analgesia without prolonging recovery.
The administration of midazolam by centroneuraxis route has been shown to produce segmental antinociception. This midazolam analgesia was found to enhance the effects of local anesthetics given in combination epidurally without any adverse effects. The present study was designed to evaluate the post-operative analgesic effect of intrathecal midazolam-bupivacaine mixture in patients undergoing knee arthroscopy. ⋯ The results suggest that addition of midazolam to bupivacaine intrathecally provided better post-operative analgesia without any adverse effects.
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Int J Clin Pharm Th · Oct 1999
Effect of plasma alpha1-acid glycoprotein concentration on the accumulation of lidocaine metabolites during continuous epidural anesthesia in infants and children.
Alpha1-acid glycoprotein (AAG) is an acute-phase protein that is responsible for binding basic drugs such as lidocaine (LDC). The effect of AAG on the duration of LDC during continuous epidural anesthesia in infants and young children was investigated. ⋯ Our results suggest that the plasma AAG concentration is a valuable index in preventing the toxicity caused by accumulation of MEGX during continuous epidural anesthesia of LDC.