Int J Clin Pharm Th
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Int J Clin Pharm Th · May 1999
Randomized Controlled Trial Comparative Study Clinical TrialComparison of caudal tramadol vs bupivacaine for post-operative analgesia in children undergoing hypospadias surgery.
In a prospective double-blind study, 40 children scheduled for hypospadias repair were allocated randomly to receive either caudal tramadol (1 mg/kg) or 0.25% plain bupivacaine (0.5 ml/kg). Postoperative pain score, side-effects and oxygen saturation (SaO2) were recorded during 24-hour observation period. ⋯ The incidence of side-effects such as vomiting was more frequent with caudal tramadol, but there was no detectable difference in SaO2. We conclude that caudal tramadol can safely be used for postoperative analgesia with a longer duration as compared to caudal bupivacaine.