Int J Clin Pharm Th
-
Int J Clin Pharm Th · May 2000
Clinical TrialEffect of chronic renal failure on the disposition of highly hepatically metabolized drugs.
The objective of this study was to investigate the effect of renal impairment on the disposition of an extensively metabolized drug, i.e., drug X. Drug X has a hepatic extraction ratio of less than 0.1 and free fraction in plasma of less than 1% in healthy volunteers. ⋯ Chronic renal disease should not be considered as an isolated event that affects only renally excreted drugs. Uremia may also modify the disposition of a highly metabolized drug by changes in plasma protein binding and/or hepatic metabolism.