Int J Clin Pharm Th
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Int J Clin Pharm Th · Aug 2000
Randomized Controlled Trial Comparative Study Clinical TrialPharmacodynamics and tolerability of acetyl starch as a new plasma volume expander in patients undergoing elective surgery.
Acetyl starch (ACS) is a new synthetic colloid solution for plasma volume expansion and is now undergoing phase II clinical trials. We compared the pharmacodynamics and tolerability of ACS with those ofhydroxyethyl starch (HES) in 32 patients (American Society of Anesthesiologists physical status I and II) undergoing elective surgery. ⋯ ACS and HES are equally effective plasma volume expanders; ACS might be a new, alternative colloid solution with fewer coagulation side-effects than HES.