Int J Clin Pharm Th
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Int J Clin Pharm Th · Sep 2010
Time course of action and pharmacokinetics of ropivacaine in adult and elderly patients following combined lumbar plexus-sciatic nerve block.
Large doses of local anesthetics are needed in combined lumbar plexus-sciatic nerve block. The safety of local anesthetics is important among elderly patients. This study investigates the pharmacokinetics of ropivacaine in elderly patients with combined lumbar plexus-sciatic nerve block. ⋯ Age does not affect the onset time of ropivacaine after combined lumbar plexus-sciatic nerve block but can influence the motor and sensory recovery. Local absorption of ropivacaine is slower in elderly patients compared to adults.