Int J Clin Pharm Th
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Int J Clin Pharm Th · Aug 2013
Randomized Controlled TrialEffect of epidural levobupivacaine and levobupivacaine with fentanyl on stress response and postoperative analgesia after total knee replacement.
Providing sufficient and convenient analgesia is crucial during the postoperative period after totalknee replacement (TKR) to enhance patient mobility and reduce stress response to surgery. The scope of this study is to compare the effects of levobupivacaine and levobupivacaine plus fentanyl on stress response and analgesic efficiency after TKR. ⋯ We have demonstrated that infusion of levobupivacaine (0.125%) in combination with fentanyl (4 μg ml-1) using PCEA suppressed stress response to surgery significantly and provided better pain relief than levobupivacaine (0.125%) alone after TKR.